Pathophysiology

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Dr. B.B Jain, Dr. Naitik D. Trivedi & Priyanka singh

ISBN – 9789387483194

B.Pharm., Second Semester

According to the syllabus based on ‘Pharmacy Council of India’

PATHOPHYSIOLOGY

Unit-I (10 Hours)

Basic Principles of Cell Injury and Adaptation: Introduction, definitions, Homeostasis, Components and Types of Feedback systems, Causes of cellular injury, Pathogenesis (Cell membrane damage, Mitochondrial damage, Ribosome damage, Nuclear damage),Morphology of cell injury – Adaptive changes (Atrophy, Hypertrophy, hyperplasia, Metaplasia, Dysplasia), Cell swelling, Intra cellular accumulation, Calcification, Enzyme leakage and Cell Death Acidosis & Alkalosis, Electrolyte imbalance.

Basic Mechanism Involved in the Process of Inflammation and Repair: Introduction, Clinical signs of inflammation, Different types of Inflammation, Mechanism of Inflammation – Alteration in vascular permeability and blood flow, migration of WBC’s, Mediators of inflammation, Basic principles of wound healing in the skin, Pathophysiology of Atherosclerosis.

Unit-II (10 Hours)

Cardiovascular System: Hypertension, congestive heart failure, ischemic heart disease (angina, myocardial infarction, atherosclerosis and arteriosclerosis).

Respiratory System: Asthma, Chronic obstructive airways diseases.

Renal System: Acute and chronic renal failure.

Unit-III (10 Hours)

Haematological Diseases: Iron deficiency, megaloblastic anemia (Vit B12 and folic acid), sickle cell anemia, thalasemia, hereditary acquired anemia, hemophilia

Endocrine System: Diabetes, thyroid diseases, disorders of sex hormones

Nervous System: Epilepsy, Parkinson’s disease, stroke, psychiatric disorders: depression, schizophrenia and Alzheimer’s disease.

Gastrointestinal System: Peptic Ulcer.

Unit-IV (08 Hours)

Inflammatory bowel diseases, jaundice, hepatitis (A,B,C,D,E,F) alcoholic liver disease.

Disease of Bones and Joints: Rheumatoid arthritis, osteoporosis and gout.

Principles of Cancer: classification, etiology and pathogenesis of cancer.

Diseases of Bones and Joints: Rheumatoid Arthritis, Osteoporosis, Gout.

Principles of Cancer: Classification, etiology and pathogenesis of Cancer.

Unit-V (08 Hours)

Infectious Diseases: Meningitis, Typhoid, Leprosy, Tuberculosis, Urinary tract infections

Sexually Transmitted Diseases: AIDS, Syphilis, Gonorrhea.