Biochemistry Book B.Pharm 2nd Semester

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» The PCI B.Pharm II Semester Biochemistry Book is a comprehensive guide for students pursuing their Bachelor of Pharmacy degree in India. This book covers the fundamental concepts of biochemistry and their relevance to pharmaceutical sciences. It covers a wide range of topics such as biomolecules, enzymes, metabolism, genetics, and molecular biology.

The book also includes practical applications of biochemistry in drug discovery, drug development, and quality control of pharmaceutical products. Written in a simple and easy-to-understand language, this book provides a thorough understanding of biochemistry, which is essential for a successful career in the pharmaceutical industry. It is an ideal reference guide for students, researchers, and practitioners in the field of pharmacy.

Authors: Dr.G. Murugananthan , Prof. (Dr.) Amredra Pratap Yadav  ISBN No.: 978-93-5755-996-6 

| Fast & All India Delivery |

| Written by Experienced Authors |

| As per approved syllabus of P.C.I. |

| With Clear Explanations and Example |

| Provides In-Depth Coverage of the Subject Matter |

Syllabus

 

Code: BP203T

 

Biochemistry

 

Unit

Contents

Hours

I

·        Biomolecules

Introduction, classification, chemical nature and biological role of carbohydrate, lipids, nucleic acids, amino acids and proteins.

 

·        Bioenergetics

Concept of free energy, endergonic and exergonic reaction, Relationship between free energy, enthalpy and entropy; Redox potential. Energy rich compounds; classification; biological significances of ATP and cyclic AMP.

08

II

·        Carbohydrate Metabolism

Glycolysis – Pathway, energetics and significance. Citric acid cycle- Pathway, energetics and significance. HMP shunt and its significance; Glucose-6-phosphate dehydrogenase (G6PD) deficiency. Glycogen metabolism pathways and Glycogen Storage Diseases (GSD). Gluconeogenesis- Pathway and its significance. Hormonal regulation of blood glucose level and Diabetes mellitus.

 

·        Biological Oxidation

Electron Transport Chain (ETC) and its mechanism.

Oxidative phosphorylation & its mechanism and substrate phosphorylation.

 

Inhibitors ETC and oxidative phosphorylation/Uncouplers.

10

III

·        Lipid Metabolism

β-oxidation of saturated fatty acid (Palmitic acid). Formation and utilization of ketone bodies; ketoacidosis.

De novo synthesis of fatty acids (Palmitic acid). Biological significance of cholesterol and conversion of cholesterol into bile acids, steroid hormone and vitamin D.

Disorders of lipid metabolism- Hypercholesterolemia, atherosclerosis, fatty liver and obesity.

 

·        Amino Acid Metabolism

General reactions of amino acid metabolism: Transamination, deamination & decarboxylation, urea cycle and its disorders. Catabolism of phenylalanine and tyrosine and their metabolic disorders (Phenyketonuria, Albinism, alkeptonuria, tyrosinemia).

Synthesis and significance of biological substances; 5-HT, melatonin, dopamine, noradrenaline, adrenaline. Catabolism of heme; hyperbilirubinemia and jaundice.

10

IV

Nucleic Acid Metabolism and Genetic Information Transfer

Biosynthesis of purine and pyrimidine nucleotides. Catabolism of purine nucleotides and hyperuricemia and gout disease. Organisation of mammalian genome. Structure of DNA and RNA and their functions. DNA replication (semi conservative model), Transcription or RNA synthesis. Genetic code, Translation or protein synthesis and inhibitors.

10

V

Enzymes

Introduction, properties, nomenclature and IUB classification of enzymes. Enzyme kinetics (Michaelis plot, Line Weaver Burke plot). Enzyme inhibitors with examples. Regulation of Enzymes- Enzyme induction and repression, allosteric enzymes regulation. Therapeutic and diagnostic applications of enzymes and isoenzymes. Coenzymes –Structure and biochemical functions.

07

 

PCI2025/Bpharm/2/03
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