Biochemistry & Clinical Pathology

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ISBN- 978-93-5480-363-5

AUTHORS - Prof. (Dr.) R. Srinivasan , Prof. (Dr.) Ajay Pal Singh ,  Prof. Devika K. Tilekar

Syllabus

Biochemistry & Clinical Pathology

Course Code: ER20-23T

 

Chapter

Topic

Hours

1)     

 

Introduction to Biochemistry: Scope of biochemistry in pharmacy; Cell and its biochemical organization.

2

2)     

 

Carbohydrates

  • Definition, classification with examples, chemical

properties

  • Monosaccharides - Structure of glucose, fructose, and

galactose

  • Disaccharides - structure of maltose, lactose, and sucrose

  • Polysaccharides - chemical nature of starch and   glycogen

  • Qualitative tests and biological role of carbohydrates

5

3)     

 

Proteins

  • Definition, classification of proteins based on

  • composition and solubility with examples

  • Definition, classification of amino acids based on

  • Chemical nature and nutritional requirements withexamples

  • Structure of proteins (four levels of organization of protein structure)

  • Qualitative tests and biological role of proteins and amino acids

  • Diseases related to malnutrition of proteins.

5

4)     

 

Lipids

  • Definition, classification with examples

  • Structure and properties of triglycerides (oils and fats)

  • Fatty acid classification - Based onchemical and nutritional requirements with examples

  • Structure and functions of cholesterol in the body

  • Lipoproteins - types, composition and functions in the body

  • Qualitative tests and functions of lipids

5

5)     

 

Nucleic Acids

  • Definition, purine and pyrimidine bases

  • Components of nucleosides and nucleotides with examples

  • Structure of DNA (Watson and Crick model), RNA and

  • their functions

4

6)     

 

 

Enzymes

  • Definition, properties and IUB and MB classification

  • Factors affecting enzyme activity

  • Mechanism of action of enzymes, Enzyme inhibitors

  • Therapeutic and pharmaceutical importance of enzymes

5

7)     

 

Vitamins

  • Definition and classification with examples

  • Sources, chemical nature, functions, coenzyme form, recommended dietary requirements, deficiency diseases of fat-and water-soluble vitamins

6

8)     

 

 

Metabolism (Study of cycle/pathways without chemical structures)

  • Metabolism of Carbohydrates: Glycolysis, TCA cycle and glycogen metabolism, regulation of blood glucose level. Diseases related to abnormal metabolism of Carbohydrates

  • Metabolism of lipids: Lipolysis, β-oxidation of Fatty acid (Palmitic acid) ketogenesis and ketolysis. Diseases related to abnormal metabolism of lipids such as Ketoacidosis, Fatty liver, Hypercholesterolemia

  • Metabolism of Amino acids (Proteins): General reactions of amino acids and its significance Transamination, deamination, Urea cycle and decarboxylation. Diseases related to abnormal metabolism of amino acids, Disorders of ammonia metabolism, phenylketonuria, alkaptonuria and Jaundice.

  • Biological oxidation: Electron transport chain and Oxidative phosphorylation

20

9)     

 

 

Minerals: Types, Functions, Deficiency diseases, recommended dietary requirements

05

10)  

 

Water and Electrolytes

  • Distribution, functions of water in the body

  • Water turnover and balance

  • Electrolyte composition of the body fluids, Dietary intake of electrolyte and Electrolyte balance

  • Dehydration, causes of dehydration and oral rehydration therapy

05

11)  

 

Introduction to Biotechnology

01

12)  

 

 

Organ Function Tests

  •  Functions of kidney and routinely performed tests to assess the functions of kidney and their clinical significances

  • Functions of liver and routinely performed tests to assess the functions of liver and their clinical significances

  • Lipid profile tests and its clinical significances

06

13)  

 

Introduction to Pathology of Blood and Urine

  • Lymphocytes and Platelets, their role in health and disease

  • Erythrocytes - Abnormal cells and their significance

  • Normal and Abnormal constituents of Urine and their significance

06

PCI2022/ D.PHARM/2/3
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