Medicinal Chemistry-I

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Buy the Latest version of Medicinal Chemistry-I book of B. pharm 4th Semester by Thakur Publication. Medicinal chemistry textbook covered all important topics.

The PCI B.Pharm 4 semester Medicinal Chemistry-I book is a comprehensive guide for pharmacy students studying the design and synthesis of drugs. This book covers essential topics such as drug-receptor interactions, drug metabolism, and structure-activity relationships, as well as advanced concepts like prodrugs and enzyme inhibitors.

With clear explanations and practical examples, this book provides a thorough understanding of the fundamental principles behind drug discovery and development. It is an essential resource for students and professionals in the pharmaceutical industry seeking to deepen their knowledge of the chemical and biological processes involved in drug action.

| Written by Experts | Fast Delivery | As per PCI Syllabus |

ISBN No.: 978-93-88280-71-6

Authors: Prof. (Dr.) R.D. Gupta, Dr. Santosh R. Kirtane, Dr. Vishal Bharat Babar

                                                                         (BP402T)- MEDICINAL CHEMISTRY - I

Module-1                                                                                    (10 Hours)

Medicinal Chemistry

  • Introduction, History and development of medicinal chemistry.

Physicochemical properties in relation to biological action

  • Ionization, Solubility, Partition Coefficient, Hydrogen bonding, Protein binding, Chelation, Bioisosterism, Optical and Geometrical isomerism.

Drug metabolism

  • Drug metabolism principles-Phase I and Phase II.
  • Factors affecting drug metabolism including stereo chemical aspects.

Module-2                                                                                    (10 Hours)

Drugs acting on Autonomic Nervous System

  • Adrenergic Neurotransmitters: Biosynthesis and catabolism of catecholamine.
  • Adrenergic receptors (Alpha and Beta) and their distribution.

Sympathomimetic Agents: SAR of Sympathomimetic Agents

  • Direct Acting: Nor-epinephrine, Epinephrine, Phenylephrine, Dopamine, Methyldopa, Clonidine, Dobutamine, Isoproterenol, Terbutaline, Salbutamol*, Bitolterol, Naphazoline, Oxymetazoline and Xylometazoline.
  • Indirect Acting Agents: Hydroxyamphetamine, Pseudoephedrine, Propylhexedrine.
  • Agents with Mixed Mechanism: Ephedrine, Metaraminol.

Adrenergic Antagonists

  • Alpha Adrenergic Blockers: Tolazoline*, Phentolamine, Phenoxybenzamine, Prazosin, Dihydroergotamine, Methysergide.
  • Beta-Adrenergic Blockers: SAR of beta blockers, Propranolol*, Metibranolol, Atenolol, Betazolol, Bisoprolol, Esmolol, Metoprolol, Labetolol, Carvedilol.

Module-3                                                                                    (10 Hours)

Cholinergic Neurotransmitters

  • Biosynthesis and catabolism of acetylcholine.
  • Cholinergic receptors (Muscarinic and Nicotinic) and their distribution.

Parasympathomimetic Agents: SAR of Parasympathomimetic Agents

  • Direct Acting Agents: Acetylcholine, Carbachol*, Bethanechol, Methacholine, Pilocarpine.
  • ‘Indirect acting/ Cholinesterase inhibitors (Reversible and Irreversible): Physostigmine, Neostigmine*, Pyridostigmine, Edrophonium chloride, Tacrine hydrochloride, Ambenonium chloride, Isofluorphate, Echothiophate iodide, Parathione, Malathion.
  • Cholinesterase Reactivator: Pralidoxime chloride.

Cholinergic Blocking Agents: SAR of Cholinolytic Agents

  • Solanaceous Alkaloids and Analogues: Atropine sulphate, Hyoscyamine sulphate, Scopolamine hydrobromide, Homatropine hydrobromide, Ipratropium bromide*.
  • Synthetic Cholinergic Blocking Agents: Tropicamide, Cyclopentolate hydrochloride, Clidinium bromide, Dicyclomine hydrochloride*, Glycopyrrolate, Methantheline, bromide, Propantheline bromide, Benztropine mesylate, Orphenadrine citrate, Biperidine hydrochloride, Procyclidine hydrochloride*, Tridihexethyl chloride, Isopropamide iodide, Ethopropazine hydrochloride.

Module-4                                                                                    (08 Hours)

Drugs acting on Central Nervous System

Sedatives and Hypnotics

  • Benzodiazepines: SAR of Benzodiazepines, Chlordiazepoxide, Diazepam*, Oxazepam, Chlorazepate, Lorazepam, Alprazolam, Zolpidem
  • Barbiturtes: SAR of barbiturates, Barbital*, Phenobarbital, Mephobarbital, Amobarbital, Butabarbital, Pentobarbital, Secobarbital

Miscelleneous

  • Amides and Imides: Glutethmide.
  • Alcohol and their Carbamate Derivatives: Meprobomate, Ethchlorvynol. Aldehyde and their derivatives: Triclofos sodium, Paraldehyde.

Antipsychotics

  • Phenothiazeines: SAR of Phenothiazeines – Promazine hydrochloride, Chlorpromazine hydrochloride*, Triflupromazine, Thioridazine hydrochloride, Piperacetazine hydrochloride, Prochlorperazine maleate, Trifluoperazine hydrochloride.
  • Ring Analogues of Phenothiazeines: Chlorprothixene, Thiothixene, Loxapine succinate, Clozapine.
  • Fluro Buterophenones: Haloperidol, Droperidol, Risperidone.
  • Beta amino Ketones: Molindone hydrochloride.
  • Benzamides: Sulpieride.

Anticonvulsants: SAR of Anticonvulsants, Mechanism of Anticonvulsant Action

  • Barbiturates: Phenobarbitone, Methabarbital.
  • Hydantoins: Phenytoin*, Mephenytoin, Ethotoin.
  • Oxazolidine Diones: Trimethadione, Paramethadione.
  • Succinimides: Phensuximide, Methsuximide, Ethosuximide*.
  • Urea and Monoacylureas: Phenacemide, Carbamazepine*.
  • Benzodiazepines: Clonazepam.
  • Miscellaneous: Primidone, Valproic acid, Gabapentin, Felbamate.

Module-5                                                                                    (07 Hours)

Drugs acting on Central Nervous System

General Anaesthetics

  • Inhalation Anesthetics: Halothane*, Methoxyflurane, Enflurane, Sevoflurane, Isoflurane, Desflurane.
  • Ultra Short Acting Barbitutrates: Methohexital sodium*, Thiamylal sodium, Thiopental sodium.
  • Dissociative Anesthetics: Ketamine hydrochloride.*

Narcotic and Non-Narcotic Analgesics

  • Morphine and Related Drugs: SAR of Morphine analogues, Morphine sulphate, Codeine, Meperidine hydrochloride, Anilerdine hydrochloride, Diphenoxylate hydrochloride, Loperamide hydrochloride, Fentanyl citrate*, Methadone hydrochloride*, Propoxyphene hydrochloride, Pentazocine, Levorphanol tartarate.
  • Narcotic Antagonists: Nalorphine hydrochloride, Levallorphan tartarate, Naloxone hydrochloride.

Anti-Inflammatory Agents

Sodium salicylate, Aspirin, Mefenamic acid*, Meclofenamate, Indomethacin, Sulindac, Tolmetin, Zomepriac, Diclofenac, Ketorolac, Ibuprofen*,Naproxen, Piroxicam, Phenacetin, Acetaminophen, Antipyrine, Phenylbutazone.

PCI2023/B.Pharm/04/2
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