Pharmacology-I

                                                                                                   BP404T: PHARMACOLOGY-I

Module 01                                                                                                                          08 hours

General Pharmacology

• Introduction to Pharmacology: Definition, Historical Landmarks and Scope of Pharmacology, Nature and Source of Drugs, Essential Drugs Concept and Routes of Drug Administration, Agonists, Antagonists (Competitive and Non-Competitive), Spare Receptors, Addiction, Tolerance, Dependence, Tachyphylaxis, Idiosyncrasy, Allergy.
• Pharmacokinetics: Membrane Transport, Absorption, Distribution, Metabolism and Excretion of Drugs. Enzyme Induction, Enzyme Inhibition, Kinetics of Elimination.

Module 02                                                                                                                         12 Hours

General Pharmacology

• Pharmacodynamics: Principles and mechanisms of drug action. Receptor theories and classification of receptors, regulation of receptors. drug receptors interactions signal transduction mechanisms, G-protein–coupled receptors, ion channel receptor, transmembrane enzyme linked receptors, transmembrane JAK-STAT binding receptor and receptors that regulate transcription factors, dose response relationship, therapeutic index, combined effects of drugs and factors modifying drug action.
• Adverse drug reactions.
• Drug Interactions (Pharmacokinetic and Pharmacodynamic).
• Drug Discovery and clinical evaluation of new drugs -Drug discovery phase, Preclinical Evaluation phase, clinical trial phase, phases of clinical trials and pharmacovigilance.

Module 03                                                                                                                           10 Hours

Pharmacology of Drugs Acting On Peripheral Nervous System

• Organisation and function of ANS.
• Neurohumoral transmission,co-Transmission and Classification of neurotransmitters.
• Parasympathomimetics, Parasympatholytics, Sympathomimetics, Sympatholytics.

Module 04                                                                                                                           08 Hours

Pharmacology of Drugs Acting On Central Nervous System

• Neurohumoral transmission in the C.N.S.special emphasis on importance of various neurotransmitters like with GABA, Glutamate, Glycine, serotonin, dopamine.
• General Anaesthetics and pre-anaesthetics.
• Sedatives, Anti-epileptics, Hypnotics and centrally acting muscle relaxants.
• Alcohols and disulfiram.
• Local anaesthetic agents.
• Drugs used in Myasthenia gravis and Glaucoma.

Module 05                                                                                                                           07 Hours

Pharmacology of drugs acting on central nervous system

• Psychopharmacological agents: Antipsychotics, Antidepressants, Anti-anxiety agents, anti-manics and hallucinogens.
• Drugs used in Parkinsons Disease and Alzheimer’s Disease.
• CNS stimulants and nootropics.
• Opioid Analgesics and Antagonists.
• Drug Addiction, Drug Abuse, tolerance and dependence.