Pharmaceutical Chemistry

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ISBN- 978-93-5480-022-1

AUTHORS- Dr. Desh Deepak Pandey, Mr. Neeraj Kumar

Syllabus

                                                                     Course Code: ER20-12T

                                                PHARMACEUTICAL CHEMISTRY

Ch

Topics

Hrs

1

Introduction to Pharmaceutical Chemistry: Scope and Objectives

Sources and Types of Errors: Accuracy, Precision, Significant Figures

Impurities in Pharmaceuticals: Source and Effect of Impurities in Pharmacopoeial Substances, Importance of Limit Test, Principle and Procedures of Limit Tests for Chlorides, Sulphates, Iron, Heavy Metals and Arsenic.

8

2

Volumetric Analysis: Fundamentals of Volumetric Analysis, Acid-base Titration, Non-Aqueous Titration, Precipitation Titration, Complexometric Titration, Redox Titration

 

Gravimetric Analysis: Principle and Method.

8

3

Inorganic Pharmaceuticals: Pharmaceutical Formulations, Market Preparations, Storage Conditions and Uses of

·         Haematinics: Ferrous Sulphate, Ferrous Fumarate, Ferric Ammonium Citrate, Ferrous Ascorbate, Carbonyl Iron

·         Antacids: Aluminium Hydroxide Gel, Magnesium Hydroxide, Magaldrate, Sodium Bicarbonate, Calcium Carbonate

·         Anti-Microbial Agents: Silver Nitrate, Ionic Silver, Chlorhexidine Gluconate, Hydrogen Peroxide, Boric Acid, Bleaching powder, Potassium Permanganate

·         Dental Products: Calcium Carbonate, Sodium Fluoride, Denture Cleaners, Denture Adhesives, Mouth Washes

·         Medicinal Gases: Carbon Dioxide, Nitrous Oxide, Oxygen

7

4

Introduction to Nomenclature of Organic Chemical Systems with Particular Reference to Heterocyclic Compounds Containing up to Three Rings

2

Study of the Following Category of Medicinal Compounds with Respect to Classification, Chemical Name, Chemical Structure (Compounds Marked with*) Uses, Stability and Storage Csonditions, Different Types of Formulations and Their Popular Brand Names

5

Drugs Acting on Central Nervous System

·         Anaesthetics: Thiopental Sodium*, Ketamine Hydrochloride*, Propofol

·         Sedatives and Hypnotics: Diazepam*, Alprazolam*, Nitrazepam, Phenobarbital*

·         Antipsychotics: Chlorpromazine Hydrochloride*, Haloperidol*, Risperidone*, Sulpiride*, Olanzapine, Quetiapine, Lurasidone

·         Anticonvulsants: Phenytoin*, Carbamazepine*, Clonazepam, Valproic Acid*, Gabapentin*, Topiramate, Vigabatrin, Lamotrigine

·         Anti-Depressants: Amitriptyline Hydrochloride*, Imipramine Hydrochloride*, Fluoxetine*, Venlafaxine, Duloxetine, Sertraline, Citalopram, Escitalopram, Fluvoxamine, Paroxetine

9

6

Drugs Acting on Autonomic Nervous System

·         Sympathomimetic Agents: Direct Acting: NorEpinephrine*, Epinephrine, Phenylephrine, Dopamine*, Terbutaline, Salbutamol (Albuterol), Naphazoline*, Tetrahydrozoline. Indirect Acting  Agents: Hydroxy Amphetamine, Pseudoephedrine. Agents With Mixed Mechanism: Ephedrine, Metaraminol

·         Adrenergic Antagonists: Alpha Adrenergic Blockers: Tolazoline, Phentolamine

·         Phenoxybenzamine, Prazosin. Beta Adrenergic Blockers: Propranolol*, Atenolol*, Carvedilol

·         Cholinergic Drugs and Related Agents: Direct Acting Agents: Acetylcholine*, Carbachol, And Pilocarpine. Cholinesterase Inhibitors: Neostigmine*, Edrophonium Chloride, Tacrine Hydrochloride, Pralidoxime Chloride, Echothiopate Iodide

·         Cholinergic Blocking Agents: Atropine Sulphate*, Ipratropium Bromide

Synthetic Cholinergic Blocking Agents: Tropicamide, Cyclopentolate Hydrochloride, Clidinium Bromide, Dicyclomine Hydrochloride*

9

7

Drugs Acting on Cardiovascular System

·         Anti-Arrhythmic Drugs: Quinidine Sulphate, Procainamide Hydrochloride, Verapamil, Phenytoin Sodium*, Lidocaine Hydrochloride, Lorcainide Hydrochloride, Amiodarone and Sotalol

·         Anti-Hypertensive Agents: Propranolol*, Captopril*, Ramipril, Methyldopate Hydrochloride, Clonidine Hydrochloride, Hydralazine Hydrochloride, Nifedipine,

·         Antianginal Agents: Isosorbide Dinitrate

5

8

Diuretics: Acetazolamide, Frusemide*, Bumetanide, Chlorthalidone, Benzthiazide, Metolazone, Xipamide, Spironolactone

2

9

Hypoglycemic Agents: Insulin and Its Preparations, Metformin*, Glibenclamide*, Glimepiride, Pioglitazone, Repaglinide, Gliflozins, Gliptins

3

10

Analgesic And Anti-Inflammatory Agents: Morphine Analogues, Narcotic Antagonists; Nonsteroidal AntiInflammatory Agents (NSAIDs) - Aspirin*, Diclofenac, Ibuprofen*, Piroxicam, Celecoxib, Mefenamic Acid, Paracetamol*, Aceclofenac

3

11

Anti-Infective Agents

·         Antifungal Agents: Amphotericin-B, Griseofulvin, Miconazole, Ketoconazole*, Itraconazole, Fluconazole*, Naftifine Hydrochloride

·         Urinary Tract Anti-Infective Agents: Norfloxacin, Ciprofloxacin, Ofloxacin*, Moxifloxacin, 

·         Anti-Tubercular Agents: INH*, Ethambutol, Para Amino Salicylic Acid, Pyrazinamide, Rifampicin, Bedaquiline, Delamanid, Pretomanid*

·         Antiviral Agents: Amantadine Hydrochloride, Idoxuridine, Acyclovir*, Foscarnet, Zidovudine, Ribavirin, Remdesivir, Favipiravir

·         Antimalarials: Quinine Sulphate, Chloroquine Phosphate*, Primaquine Phosphate, Mefloquine*, Cycloguanil, Pyrimethamine, Artemisinin

·         Sulfonamides: Sulfanilamide, Sulfadiazine, Sulfametho xazole, Sulfacetamide*, Mafenide Acetate, Cotrimoxazole, Dapsone*

8

12

Antibiotics: Penicillin   G, Amoxicillin*, Cloxacillin, Streptomycin, Tetracyclines: Doxycycline, Minocycline, Macrolides: Erythromycin, Azithromycin, Miscellaneous: Chloramphenicol* Clindamycin

8

13

Anti-Neoplastic Agents: Cyclophosphamide*, Busulfan, Mercaptopurine, Fluorouracil*, Methotrexate, Dactinomycin, Doxorubicin Hydrochloride, Vinblastine Sulphate, Cisplatin*, Dromostanolone Propionate

3

PCI2021/D.Pharma(English)/1/02
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