Zoology,Gene Technology, Immunology and Computational Biology (जीन प्रौद्योगिकी,प्रतिरक्षा विज्ञान एवं कम्प्यूटेशनल जीवविज्ञान)

Unit

¼bdkbZ½

Topic ¼fo"k;½

Total No. of

Lectures (60)

¼O;k[;kuksa dh dqy la[;k ¼60½

I

Principles of Gene Manipulation

·      Recombinant DNA Technology

·      Selection and identification of recombinant cells

·      Restriction enzymes, DNA Modifying Enzymes, Cloning Vectors, Ligation

·       Gene transfer techniques, Gene therapy

thu gsjQsj ds fl)kar

·      iqu% la;kstd DNA çkS|ksfxdh

·      iqu% la;kstd dksf'kdkvksa dk p;u vkSj igpku

·      çfrcaf/kr ,atkbe] DNA :ikarfjr ,atkbe] Dyksfuax osDVj] ykbxs’ku

·      thu LFkkukarj.k rduhd] thu Fksjsih

10

II

Applications of Genetic Engineering

·      Single cell proteins

·      Biosensors, Biochips

·      Crop and live stock improvement, Development of transgenics

·      Development of DNA drugs and vaccines

vkuqoaf'kd vfHk;kaf=dh ds vuqç;ksx

·      ,dy dksf'kdk çksVhu

·      ck;kslsalj] ck;ksfpIl

·      Qly vkSj i'kq/ku lq/kkj] Vªkaltsfud dk fodkl

·      DNA nokvksa vkSj Vhdksa dk fodkl

8

III

DNA Diagnostics

·      Genetic analysis of human diseases, Detection of known and unknown mutations

·      Concept of pharmacogenomics and pharmacogenetics

Mh,u, uSnkfudh

·      ekuo jksxksa dk vkuqoaf'kd fo'ys"k.k] Kkr vkSj vKkr mRifjorZu dk irk yxkuk

·      QkekZdkstsuksfeDl vkSj QkekZdkstsusfVDl dh vo/kkj.kk

4

IV

Immune System and its Components

·      Historical perspective of Immunology, Innate and Adaptive Immunity, Clonal selection, Complement system

·      Structure and functions of different classes of immunoglobulins, Hypersensitivity

·      Humoral immunity and cell mediated immunity

·      HLA complex: Organisation, class I and II HLA molecules

çfrj{kk ra= vkSj blds ?kVd

·      çfrj{kk foKku] tUetkr vkSj vuqdwyh çfrj{kk] Dyksuy p;u] iwjd ra= dk ,sfrgkfld ifjçs{;

·      bE;quksXykscqfyu] vfrlaosnu'khyrk ds fofHkUu oxksaZ dh lajpuk vkSj dk;Z

·      g~;weksjy çfrj{kk vkSj dksf'kdk e/;LFkrk çfrj{kk

·      HLA d‚EIysDl& laxBu] oxZ I vkSj II HLA v.kq

10

V

Biostatistics I

·      Calculations of mean, median, mode, variance, standard deviation

·      Concepts of coefficient of variation, Skewness, Kurtosis

·      Elementary idea of probability and application

tSo lkaf[;dh I

·      ek/;] ekf/;dk] cgqyd] fopj.k] ekud fopyu dh x.kuk

·      fofHkUurk dk xq.kkad] frjNkiu] djVksfll dh vo/kkj.kk

·      çkf;drk vkSj vuqç;ksx dk çkjafHkd fopkj

7

VI

Biostatistics II

·      Data summarizing: Frequency distribution, Graphical presentation—Bar, Pie diagram, Histogram

·      Tests of significance: One and two sample tests, t-test and Chisquare test

tSo lkaf[;dh II

·      vk¡dMksa dk lkjka’k& vko`fÙk forj.k] xzkfQdy çLrqfr& ckj] ikbZ vkjs[k] fgLVksxzke

·      egRo ds ijh{k.k& ,d vkSj nks uewuk ijh{k.k] t-ijh{k.k vkSj fpLdos;j ijh{k.k

7

VII

Basics of Computers

·      Basics (CPU, I/O units) and Operating systems

·      Concept of homepages and websites, World Wide Web, URLs, using search engines

daI;wVj dh ewy ckrsa

·      ewy ckrsa ¼CPU, I/O bdkb;ka½ vkSj v‚ijsfVax flLVe

·      gkseist vkSj osclkbVksa dh vo/kkj.kk] oYMZ okbM osc] URLs] lpZ batu dk mi;ksx djuk

6

VIII

Bioinformatics

·      Databases: Nucleic acids, Genomes, Protein sequences and structures, Bibliography

·      Sequence analysis (homology): Pairwise and Multiple sequence alignments-Blast, Clustalw

·      Phylogenetic analysis

tSo lwpuk foKku

·      MsVkcsl& U;wfDyd vEy] thukse] çksVhu vuqØe vkSj lajpuk,a] fcfCy;ksxzkQh

·      vuqØe fo'ys"k.k ¼letkrrk½& tksM+hnkj vkSj cgq vuqØe lajs[k.k& Blast, Clustalw

·      tkfro`Ùkh; fo'ys"k.k

8